Of course it's possible! In fact, this is one of the easiest frames to work on, as it doesn't require any radical modifications. All you need to do is move the crossbar that connects the upper or lower chainstays (depending on the model), leaving enough space for the wheel to pass through.
On the latest 26-inch Scalpel model, for example, you need to move the crossbar of the upper chainstays by about 1 cm, whereas on the previous model you need to work on the lower one.
Just this month, I made three modifications of this kind, also working on the upper shock absorber bushings: I created new ones with an offset hole in order to recover, at least in part, the increase in ground clearance of the bottom bracket that the installation of 650 B wheels inevitably entails (+1.5 cm). As for the Lefty fork, no modification is necessary, but it is a good idea to check it beforehand by deflating it completely to make sure that, at the end of its travel, the wheel does not touch the lower plate of the fork.